A recent study conducted at Mass General Brigham has found a potential link between head injuries and an elevated risk of developing brain cancer. The researchers analyzed data collected from over 75,000 people with traumatic brain injuries that ranged from mild to severe between 2000 and 2024, and discovered that patients with a history of suffering traumatic brain injury (TBI) were more likely to develop malignant brain tumors compared to patients who had not experienced traumatic brain injuries in the past.
Sometimes referred to as intracranial injuries, TBIs occur when external mechanical forces such as rapid deceleration or acceleration, shock waves, or impact cause the brain to slam against the inside of the skull and sustain damage.
Depending on the severity of the damage dealt to the brain, patients who suffer traumatic brain injuries can experience behavioral, emotional, social, and cognitive side effects that range from mild and easily treatable to permanent disability and, in the most extreme cases, death. The recent Mass General Brigham report now suggests that patients who survive traumatic brain injuries may develop an elevated malignant brain tumor risk.
The paper adds to a growing body of research that has found traumatic brain injuries to be chronic medical conditions, rather than one-time injuries, that can impact a patient’s health over the long term.
The Brain Injury Association of America estimates that over 5 million Americans (1 in 60) are currently living with a permanent TBI-related disability, making traumatic brain injury one of the largest causes of disability in the country.
Additionally, the association notes that brain injury can have a wide variety of long-term effects that include trouble with executive functioning and focus, chronic migraines, depression and anxiety, fatigue, memory loss, sensitivity to light and noise, and increased risk of developing chronic traumatic encephalopathy (CTE), Parkinson’s disease, stroke, and Alzheimer’s disease.
Researchers from Mass General Brigham previously found a link between cardiovascular disease and traumatic brain injury. Coupled with the recent results indicating that malignant brain tumors may also affect TBI patients at a greater rate than those who didn’t experience TBIs in the past, there is a significant need for lifelong vigilance in patients with a history of TBIs, instead of treating TBIs as one-time medical events.
Mass General Brigham researchers teamed up with scientists from the University of California, San Francisco, the University of Missouri, Northwestern University, and the University of Texas Health Science Center, and published their findings in JAMA Network Open.
Plenty of research resources are being invested by companies like CNS Pharmaceuticals Inc. (NASDAQ: CNSP) to develop treatments for brain malignancies in pediatric and adult patients. With the current rise in brain cancer cases, the anticipated success of these drug development efforts offers hope to those who develop these cancers as a result of TBIs or other causes.
NOTE TO INVESTORS: The latest news and updates relating to CNS Pharmaceuticals Inc. (NASDAQ: CNSP) are available in the company’s newsroom at https://ibn.fm/CNSP
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