Scientists Find Targeting Enzyme That Could Block Brain Metastases
Researchers from King's College London and McMaster University have made a discovery that could fundamentally change how doctors treat brain cancer. The team identified a molecular pathway that appears critical to cancer's ability to migrate to the brain. Working with a commercial partner called Block Biosciences, they created drug candidates designed to block this process. This work represents a shift from treating cancer after it spreads to preventing that spread in the first place. The enzyme, IMPDH2, which appears in two separate versions within human cells, emerged as the key target for intervention. Only one version plays a role in…

