Scientists Discover Why Immunotherapy Frequently Fails
Although cancer immunotherapy has transformed treatment for many patients, the promise of effective immunotherapy falls short for many patients. Scientists now believe they have identified a major reason why immunotherapy isn't always effective. New research shows that cancer cells rely on a previously hidden escape route to weaken immune attacks, and a class of widely used medications may help block it. The study, led by Professor Kunihiro Tsuchida at Fujita Health University, suggests that cancer cells do more than evade immune checkpoints. They actively distribute immune-suppressing signals throughout the body, reducing the effectiveness of immunotherapy even when tumors appear responsive based on standard markers. Immunotherapy drugs such as PD-1 and PD-L1 inhibitors work by releasing the…

