Researchers Create Less Toxic, More Effective Immunotherapy Against Blood Cancer
University of North Carolina scientists have engineered immune cells that can destroy acute myeloid leukemia while sparing healthy blood tissue, overcoming a limitation that has plagued standard treatments, which have struggled to separate cancerous cells from normal cells. Immunologist Gianpietro Dotti and hematologist Paul Armistead directed research teams whose work appears in the journal Blood, offering an approach that may expand options for patients battling this deadly disease. Acute myeloid leukemia afflicts adults and children alike, with diagnoses rising steadily, particularly across America and countries experiencing population aging. The malignancy typically advances rapidly through the bone marrow and bloodstream once it develops. Unfortunately, existing therapies damage normal blood-forming…

