Study Identifies Key Enzyme That Could Be Targeted to Fight Brain Cancers
Researchers at Ohio State University Medical Center have identified a key enzyme that may be used to combat one of the deadliest types of brain cancer. Known as PGM3, this enzyme plays a critical role in the hexosamine biosynthesis pathway, which contributes to rapid tumor growth through protein and lipid glycosylation. Targeting PGM3 could significantly improve glioblastoma treatment outcomes. Glioblastomas are highly malignant tumors that typically form in the brain or spinal cord. They spread rapidly from their onset, causing increased intracranial pressure and symptoms such as headaches, nausea, drowsiness, blurred vision, seizures, and personality changes. These tumors are particularly…
