Existing Cancer Drug Shows Potential in Reactivating Immunotherapy
An already approved cancer drug called Carfilzomib may help restore the effectiveness of CAR-T cell therapy in advanced multiple myeloma cases. Technical University of Munich researchers have discovered a molecular mechanism that causes cancer cells to evade treatment and have shown that blocking it can make immunotherapy work again in some patients. CAR-T cell therapy involves removing a patient's T cells, genetically altering them in the laboratory, and reintroducing them so they can recognize and attack cancer cells. For multiple myeloma, these engineered cells target a molecule known as BCMA, which appears on diseased plasma cells. The approach can extend survival, sometimes by years,…

